Nanoparticles - Uses for Supercritical Fluids

Uses for Supercritical Fluids


The use of nanoparticles in all areas is ever increasing. While the existence of nanoparticles is not new, using Supercritical Fluids (SCF) to create them is.


Using Supercritical Fluids


The use of Supercritical Fluids to make particles eliminates the shortcomings of traditional methods. There are number of SCF techniques to produce particles of controlled size and morphology for organic molecules in the sub micron range:


RESS-Rapid Expansion of a Supercritical Solution

With RESS, material is dissolved in the supercritical fluid and then depressurised though a nozzle.


GAS- Gas Anti-Solvent

Here the compound is dissolved in an organic solvent, a supercritical fluid is introduced, expanding the volume and lowering the solvents solvent strength causing the compound to precipitate under controlled conditions of particle formation.


PCA- Precipitation by Compressed Fluid Anti-Solvent

With PCA, the compound dissolved in an organic solvent is sprayed into a SCF, casuing supersaturation and solute precipitation.


SEDS -Solution Enhanced Dispersion of Supercritical Fluids

Using SEDS, the compound is dissolved in an aqueous solution and the simultaneously sprayed through a coaxial nozzle with an organic solvent into the supercritical fluid. The water is dissolved into the solvent and SCF causing supersaturation and precipitation.

Nanoparticles of inorganic compounds can also be produced using supercritical fluids and sub-critical fluids. Thermal decomposition and hydrothermal syntheses are but two ways to accomplish this.


Applied Separations can provide you with the means to make both organic and inorganic particles.



Applied Separations have a proven commitment to advancing Supercritical Fluids technology and have worked with companies all over the world to incorporate supercritical fluid extraction (SFE) into their processes. Thanks to their world class R&D team, in-house engineers, and visionary approach, Applied Separations work hard to develop and enhance applications of this green technology in many unexpected industries.


Have an application in mind? Please contact iBiosys Solutions and, together with Applied Separations, we will work with you to develop a supercritical fluid application fit for your needs.